Debate over new breast cancer screening recommendations

It’s been all over the news this week–the US Preventative Services Task Force came out with a new set of recommendations for breast cancer screening, including recommending against yearly mammograms for women ages 40-49.  Their recommendations say that there is only a small benefit from starting testing at 40, and that this benefit isn’t enough to outweigh potential harms of testing, including psychological harms, unnecessary biopsies, and false positives.

Image: http://webclipart.about.com/od/ribbonclip/l/blbc1.htm

Image: http://webclipart.about.com/od/ribbonclip/l/blbc1.htm

The task force also recommends against teaching breast self-examination, another issue that raises controversy.  Alison wrote a post a couple months ago about whether breast self exams are beneficial, take a look to get a couple more viewpoints on the issue.

The main point is that starting routine mamography at age 40 doesn’t save or add years to enough women’s lives to recommend screening for everyone.  But mammography does sometimes detect cancer in women in their 40s, and these recommendations have many people worried that insurance may stop covering mammograms for women under 50.  Since the task force states, “the decision to start regular, biennial screening mammography before the age of 50 years should be an individual one and take patient context into account, including the patient’s values regarding specific benefits and harms,” it seems unlikely that insurance companies will be able to refuse coverage for women whose physicians believe they should get earlier testing.  Women with a strong family history of breast cancer or with genetic mutations that predispose them to the disease will still be encouraged to start testing earlier.

Keep in mind that these recommendations aren’t from some random group of government officials with no knowlegde of healthcare out to save money at the cost of peoples health; on the contrary, members of the task force include mostly physicians and professionals with degrees in public health and nursing from across the country.

If you want to see the details for yourself, you can take a look at the USPSTF recommendation summary itself, or articles from CNN.com and the New York Times ).

IWHR Monthly Forum: Dr. Celeste Watkins-Hayes

Image: http://www.northwestern.edu/ipr/people/watkins.html

Image: http://www.northwestern.edu/ipr/people/watkins.html

The Institute for Women’s Health Research held its monthly forum on Tuesday with speaker Dr. Celeste Watkins-Hayes giving her talk entitled, “‘Dying from’ to ‘living with’ HIV/AIDS: Framing Institutions and the coping process of infected black women.

Dr. Watkins-Hayes began her talk by highlighting the huge discrepancies in HIV/AIDS occurrence by race: through 2007, 60% of women with HIV/AIDS were black or African-American identified. The statistics are even more striking in the local Chicago area: blacks in Chicago account for 55% of HIV/AIDS incidence, while only being 36% of the entire population. Similarly shocking, black women in Chicago account for 76% of all HIV/AIDS occurrences in the city.

The remainder of the talk discussed the results of the Sister to Sister study that Dr. Watkins-Hayes performed in Chicago. The study worked with 25 women with HIV/AIDS through two in-depth interviews and one other observation session where the woman’s health status was known and salient. The participants had an average age of 36, all had children, and the majority had low income (<15K/year).

The crux of Dr. Watkins-Hayes’ argument is that many individuals can serve as “framing institutions” for a woman diagnosed with HIV or AIDS, these are the people or communities that give the initial information about health status, give a framework for how to understand the social meaning of the illness, give women a language to discuss their diagnoses, and offer resources for dealing with the implications of their disease.  Often, these institutions are the doctors and nurses that give the initial HIV or AIDS status, but they can also be as diverse as drug and alcohol abuse rehabilitation centers that are targeting very different problems than an HIV/AIDS, or pastors and private therapists. These people, rather than friends or family, seem to be responsible for shaping how women really look at the disease and begin to accept it. If these framing institutions are not supportive or shaming about the health diagnoses, women are less likely to begin to transition to “living with” their disease. While middle and upper class women are more likely to have access to private framing institutions, lower income women are at significant risk, due to lack of time, money, or acess, of not finding strong, positive framing institutions.

I urge you all to check out Dr. Watkins-Hayes biography page; on it you will find a link to the website she helps organize, links to some of her excellent publications, and descriptions of her current projects. One of her major upcoming projects is a large scale study of the social implications of HIV/AIDS for African-American women. If you’d like to hear more about the study, or discuss being a participant, please contact one of the students working with Dr. Hayes Watkins on the project, Amanda Armour at ara@u.northwestern.edu or 312-320-1223.

The Shriver Report: A Woman’s Nation Changes Everything

Women now comprise half of all American workers, and women are either the primary or co-breadwinners for two thirds of all American families. Maria Shiver, in conjunction with the Center for American Progress, published a fascinating new report last month that outlines the ways that having a large female workforce is changing the landscape of American business, family, and health status.  The entire 400 page report can be downloaded by chapter, or read online here.

Image: americanprogress.com

Image: americanprogress.com

Of primary interest to the readers of this blog is the chapter about the health of the working woman entitled, “Sick and Tired: Working Women and their Health” by Jessica Arons and Dorothy Roberts. A few really interesting points that I’d like to pull out:

  • A quarter of women still receive insurance through their husband’s employers. This means if something happens to her husband, or a couple decides to divorce, a woman could very quickly lose her coverage.
  • There currently seems to be a two-tier system in the business place with regards to breastfeeding: professional mothers are accommodated, while working-class mothers are not.
  • Women are often exposed to chemicals that can impair fertility while in the workplace. Alternatively they are excluded from certain male-dominated fields because of concerns over these chemical impacts, rather than just making these workplaces safer.
  • The act of being a caregiver, which is usually done by women, can have health impacts: caregivers are more likely to report having heart disease, cancer, diabetes, and arthritis. The chronic stress felt causes women to also be more likely to suffer from stress-induced headaches, sleeplessness, irritability, and depression.
  • Women are more likely than men to work in jobs that are low-wage, part-time, or for small businesses; all are positions that infrequently offer employer-based insurance.
  • The practice of “gender rating,” or charging women more than men for insurance premiums, is common among private insurers. They are also more likely to deny coverage or increase premiums for women based on preexisting conditions that only or disproportionately affect women.
  • Because they have to pay more for insurance, and make less than men, women spend a higher percentage of their income on healthcare. They are more likely to be forced into medical bankruptcy when things go wrong.

The article has a lot of good personal stories to illustrate some of the hardships encountered with healthcare for working women, and really touches on the ways that race and economic status can put certain women at even more of a disadvantage. The chapter is such a great look at the ways that we, as working women, are impacted differently by the types of jobs we have, the influences of these jobs (and our non-paying jobs as caregivers) on our health, and the ways we are able to afford our healthcare. I highly recommend checking it out; it can be directly downloaded here.

Why Apply to the Oncofertility Saturday Academy?

DSC00578Recruitment for Oncofertility Saturday Academy (OSA) 2010 applicants officially began on Monday, November 9, 2009.  This is the fourth consecutive year of OSA and we are expecting a very competitive pool of applicants from Young Women’s Leadership Charter School.  OSA was initiated in 2007 by the Northwestern University and Young Women’s Leadership Charter School (YWLCS) of Chicago Science Partnership.  Since its inception, a total of 46 YWLCS high school girls have participated in the OSA.   Today, of the 46 students, two are college juniors, 15 are college sophomores, 14 are college freshman and 15 are 12th graders in high school.  Of the 31 who are in college, most are actively pursuing science-related majors. OSA Directors and Coordinators will be contacting and surveying all OSA Alums this year to gather information about their most current academic and careers pursuits.  Currently, OSA is also developing mechanisms and opportunities to provide long-term mentoring and support to the participants as they make the transition from high school to college and beyond.

OSA is hoping that the 31 OSA Alums will post comments on this blog to give reasons to the current YWLCS 11th and 12th grade students to apply to OSA.

  • What did you like most about OSA?
  • How did OSA help you make decisions about your academic or career path?
  • How did OSA impact your life?

OSA Alums this is an opportunity for you to give guidance to the next group of OSA participants.  Here are the names of the OSA Alums:

Chanel, Shardey, Nicole, Angelica, Ashley A. Antavia, Guadalupe, Christina, Jasmine F., Ashley M., Antavia, Natalia, Megan, Jasmine S., Yasmine, Deja, Alex, Samantha, Nikki, Mona, Grace, Chloe, Eboni, Abigail, Jathia, Kirsa, Iesha, Brittany, Shaquita, Jasmine W. and Jasmine P.

20090220_3004The Institute for Women’s Health Research created the Women’s Health Science Program for High School Girls and Beyond (WHSP).  The Oncofertility Saturday Academy (OSA) is one of the four academies offered by WHSP to inspire and prepare the next generation of women leaders in science and medicine. To promote and encourage the high school girls to take action and live healthier lives, health workshops, nutritious meals and fitness classes are integrated into every academy. To learn more about all four academies, please visit whsp.northwestern.edu.

Thank you Nikki Cooper and Grace Gallegos for posting comments to the blog.  Here are a couple photos of you in action during OSA!  Other OSA Alumni, if you make a comment, I will post your photo!

20090220_2770

Nikki Cooper, OSA Alumni, Future General Surgeon

Grace Gallegos, OSA Alumni, Future Paramedic and Nurse

Grace Gallegos, OSA Alumni, Future Paramedic and Nurse

Megan (on far left) with her OSA sisters.  Megan worked as an OSA Alumni Lab Fellow this past summer in Dr. Woodruff's lab.

Megan Romero (on far left) with her OSA sisters. Megan worked as an OSA Alumni Lab Fellow this past summer in Dr. Woodruff's lab.

Abigail Johnson isolated follicles in Dr. Woodruff's lab.

Abigail Johnson isolated follicles in Dr. Woodruff's lab.

Ashley McKinney is a sophomore at Hampton University.  Ashley was an OSA Alumni Lab Fellow this summer in Dr. Woodruff's laboratory. SCIENCE RULES!

Ashley McKinney is a sophomore at Hampton University. Ashley was an OSA Alumni Lab Fellow this summer in Dr. Woodruff's laboratory. SCIENCE RULES!

Shardey is one of the most experienced OSA leaders.  She is now a junior in college and majoring in forensic science.

Shardey is one of the most experienced OSA leaders. She is now a junior in college and majoring in forensic science.

Samantha Torres with the da Vinci surgical robot.

Samantha Torres with the da Vinci surgical robot.


Inequalities in Global Women’s Health

Guest blog by Dr. Jennifer Hirshfeld-Cytron, Reproductive Endocrinology and Infertility Fellow, Department of Obstetrics and Gynecology, Northwestern Memorial Hospital

The Obstetrics and Gynecology Grand Rounds this morning was given by past FIGO (International Federation of Gynecology and Obstetrics) and previous chairman of the department, Dr. John Sciarra.  He provided an incredibly informative and moving description of the global issues affecting women, particularly in the developing world.  He highlighted the issues of maternal mortality, maternal morbidity, STDs, cervical cancer, and education inequality.

For instance, in Afghanistan, 1 in 6 women will DIE from pregnancy related complications compared to 1 in 4100 in the developed world.  Pregnancy related complications include: abortion related deaths, hemorrhage, thrombotic events and eclampsia (see below). 20.5 million unsafe abortions occur each year worldwide and account for 60,-80,000 deaths.

Image: http://www.who.int/making_pregnancy_safer/topics/maternal_mortality/en/index.html)

Image: http://www.who.int/making_pregnancy_safer/topics/maternal_mortality/en/index.html)

Furthermore, HIV/AIDS accounts for 11% of worldwide deaths with approximately 47 percent of the 34.3 million adults living with HIV/AIDS being women. Cervical cancer, a preventable cancer with appropriate screening, sex education and potentially the vaccine, affects 200,000 women worldwide and is second only to breast cancer in incidence.  Cervical cancer screening in the developed world centers on cytology, which is not available in the developing world. He further highlighted the inequities of women.   Worldwide women work 66% more than men but receive only 15% of the income.  Illiteracy in parts of the developing worth is greater than 65% for women. This just begins to highlight the complicated issue of providing appropriate family planning education to the developing world.

These staggering and incredibly disturbing statistics leave us with only one question; how can we raise the status of women worldwide? Efforts are being done to partner developed with developing world medical schools to increase technical skills for the care of women, such as safe abortions.  A website (www.glowm.com) has been started by Dr. Sciarra and others providing education in the form of book chapters and how-to videos to begin to enhance knowledge to the developing world.  Access is huge problem for women and foundations such as the Bill and Melinda Gates Foundation are working towards these and other efforts.  In short, get involved.

As Mahmoud Fathalla, past president of the International Federation of Gynecology and Obstetrics, said: “Women are not dying because of diseases we cannot treat. They are dying because societies have yet to make the decision that their lives are worth saving.”

Do women need such big flu shots?

Dr. Sabra L. Klein, an assistant professor of molecular microbiology and immunology at the Johns Hopkins Bloomberg School of Public Health, and Phyllis Greenberger, the president and chief executive of the nonprofit Society for Women’s Health Research, recently wrote an opinion piece for the New York Times called, “Do Women Need Such Big Flu Shots?“.

Image: McAlpin, NYdailynews.com

Image: McAlpin, NYdailynews.com

The gist of their argument is actually based on the same idea as many of our recent blog entries: women, on average, have a much stronger immune system than men. The authors cite studies that demonstrate that women produce more antibodies in response to the same vaccine dose than men do. The authors conclude that women could therefore be given a smaller dose of the H1N1 flu vaccine and still get the same protection; the vaccine that is saved by giving women smaller doses would allow more people to get the much in-demand shot.

It’s an interesting hypothesis that really highlights the need for more gender-aware research and clinical trials. Sure, women were included in the clinical trials of the vaccine, but were they ever tested with a more tailored dosage? I’d guess not; I’d imagine the tests were more simply on the efficacy of the standard, male-tailored dose in women, not on whether a different dose could work as well. I applaud the article for highlighting these questions that definitely need to be addressed!

November is American Diabetes Month!

Diabetes mellitus is an endocrine disease affecting approximately 7% of the US population.  Diabetes is categorized into two classes: Type 1, or insulin dependent diabetes, and Type 2, or adult onset diabetes.

Type 1 Diabetes is a condition in which the pancreas produces little or no insulin, a hormone necessary for the metabolism of glucose.  Type 1 Diabetes is generally diagnosed in childhood or early adolescence and is considered to be primarily genetic in origin.  Symptoms include extreme hunger, fatigue, rapid weight loss and blurry vision.  There is no cure for Diabetes, but successful treatment includes insulin injections, blood sugar monitoring, a healthy diet, and regular exercise.

http://www.babble.com/CS/blogs/strollerderby/2009/02/diabetes_0.jpg

http://www.babble.com/CS/blogs/strollerderby/2009/02/diabetes_0.jpg

Type 2 Diabetes accounts for 90-95% of all Diabetes cases in the United States.  In Type 2 Diabetes, the body is either insulin resistant or the pancreas does not produce enough insulin.  This type is often preventable and is strongly linked to obesity.  Symptoms are similar to Type 1 Diabetes but, depending on the severity, treatment may only include blood sugar monitoring, a healthy diet, and regular exercise.  Severe or advanced cases may require medication and/or insulin injections.

Resources at Northwestern for Diabetes:

The Division of Endocrinology at Northwestern Memorial Hospital provides comprehensive diagnosis and treatment for a variety of endocrine related disorders.  Physicians in the department specialize in endocrine tumors, endocrine disease genetics, gestational diabetes, and offer specialized services in diagnosis and treatment of Type 1 and Type 2 Diabetes.  The department participates in a variety of NIH-sponsored research trials.  Results from NMH’s participation in the National Institute’s of Health 10-year study on prevention of type 2 diabetes can be found at http://www.feinberg.northwestern.edu/news/2009C-October/Diabetes.html.

Click to see physician finder:

http://nmhphysicians.photobooks.com/

Northwestern Physicians/ Researchers specializing in Diabetes treatment:

The Division of Endocrinology, Metabolism, and Molecular Medicine at Northwestern University features a diverse faculty, many of whom are leaders in their field.  The department, headed by Dr. Andrea Dunaif, is committed to clinical and basic science research development and training.  The research interests of the department are diverse and extend to multiple subfields of endocrinology.  Researchers studying diabetes include Dr. Franck Mauvais-Jarvis, who studies the role of estrogen receptors in pancreatic cells, Dr. M. Geoffrey Hayes, PhD, who studies the genetic components of diabetes, and Dr. Boyd E. Metzger, MD, whose research on gestational diabetes has been widely published.

IWHR Highlighted Researcher

Dr. Robert F Kushner, MD, MS is the Clinical Director of the Northwestern Comprehensive Center on Obesity and a Professor of Medicine at the Feinberg School of Medicine.  Dr. Kushner has published various books, book chapters, and articles and serves on the editorial board of various prestigious journals including Obesity, Obesity Management, and the Journal of the American Dietetic Association.  Popular publications include Dr. Kushner’s Personality Type Diet, Treatment of the Obese Patient and Fitness Unleashed: A Dog and Owner’s Guide to Losing Weight and Gaining Health Together.  Although Dr. Kushner’s research interests are in obesity and nutrition, his research and publications have implications for a diabetic population.  Recently he published a study in Obesity examining various lifestyle interventions for prevention of weight gain in type II diabetic patients taking the common diabetes medication pioglitazone (Actos®).  The study showed that the weight gain side effects commonly associated with this medication can be diminished or alleviated by lifestyle interventions such as medical nutrition therapy (MNT).  The greatest success was seen in patients who received intensive follow up MNT, which included lessons in meal planning, food preparation, goal-setting and exercise recommendations.

For information on Dr. Kushner or to purchase his books:

http://www.counselingoverweightadults.com/

Other Useful Links and Resources:

http://www.nlm.nih.gov/medlineplus/diabetes.html
http://www.cdc.gov/diabetes/
http://www.diabetes.org
http://www.dlife.com/

High School Girls Pursuing Science and Health Careers Attend a Professional Meeting: 2009 Illinois Women’s Health Conference

Aryana, Kathryn, Jenaun, Estella and Geeleeyaw at the 2009 Illinois Women’s Health Conference.

Aryana, Kathryn, Jenaun, Estella and Geeleeyaw at the 2009 Illinois Women’s Health Conference.

On Wednesday, October 28, 2009, five high school senior girls, who are participants of the Women’s Health Science Program for High School Girls and Beyond (WHSP), whsp.northwestern.edu, attended the 2009 Illinois Women’s Health Conference, http://www.idph.state.il.us/about/womenshealth/events.htm, in Oak Brook, Illinois.  To be selected, the high school girls had to write essays to explain why they wanted to attend the conference.  All the girls shared very thoughtful and meaningful reasons for wanting to participate in this opportunity.  To highlight a few of the student responses, Jenaun shared that she wanted to attend because she is still undecided on her college major and career choice and thought that participating in the conference would broaden her knowledge of the healthcare career options. Geeleeyaw thought that this would be a good opportunity for her to meet new people and talk to clinicians about her interests in pursuing a career in the healthcare field.   Lastly, Aryana wanted to attend because she is passionate about women’s health and wants to play an active role in supporting and improving the health of women.

The high school girls gained valuable and useful experiences and knowledge at the conference.  Upon arrival the high school girls checked in and received their conference nametag, bag, and materials.  The high school girls attended multiple sessions, including:

  • Cardiovascular Disease in Disparate Populations: The Facts – and What We Should Do
  • Breast Cancer – Reconstruction After the Fact
  • Energy for Life: Strategies for Peak Performance and Whole Body Wellness
  • Nutrition and Women’s Health – Health Foods or Healthy Foods
  • The Practical Clinical Approach to Women’s Sexuality

Students were expected and encouraged to take notes and ask the presenters questions at each of the sessions.

At the end of the day, the girls completed the conference evaluation form and submitted it to the conference staff.  They all expressed that they greatly appreciated this opportunity because, as the only high school students in attendance, they were able to get firsthand experience interacting with real healthcare professionals.  With the two educators who coordinated the opportunity, Megan Faurot, Director of Education Programs at the Institute for Women’s Health Research, and Kathleen Grimes, Science Department Coordinator at Young Women’s Leadership Charter School, the girls discussed what colleges they were applying to and how they plan on pursuing their career goals.   Kathryn wants to pursue a career in animal science and Estella is planning on combining her love of cooking and science to become a dietitian or nutritionist.   WHSP will continue to support and encourage all of these girls as they make the transition from high school to college and beyond to become the next generation of women leaders in science and medicine.

Is there a good way to recieve bad news?

Image: bodyandmore.auburnpub.com

Image: bodyandmore.auburnpub.com

Medscape Today recently wrote an article detailing the physician’s dilemma regarding delivering test results, and how this may differ based whether the results are normal or identify a potentially dangerous problem. Much of the discussion uses PAP smear results as way to discuss the issue: it something women are supposed to do fairly regularly, and the results can be life-changing. In the article, doctors discuss whether a phone call is the best way to deliver results. If so, who should do the calling: the doctor or a nurse? The general conclusion seemed to be that a form letter or nurse’s call is sufficient for normal test results, but that the doctor should do the notification for abnormal results. Interestly, the mode of doctor notification was disagreed upon: some doctors made phone-calls, others required appointments. I found some of the quotes on the topic annoying:

“”Patients with multiple questions are offered an appointment,” says an internist. “I am not going to provide unreimbursed care that includes lengthy phone calls.” An ob/gyn agrees. “If I am going to spend more than 2 minutes talking to a patient, the reality of reimbursement is that it must be a billable visit. The patient needs to come in.”"

I will say that other doctors disagreed and found this practice as gouging as I did. Either way, it’s obvious that the issue is still up for debate. What do you all think? How would you prefer to receive test results? What do you think are your particular healthcare provider’s motivations for delivering news as he or she does?

The complexities of estrogen signaling

Did you know that males require estrogen for many key biological processes, including spermatogenesis? Actually, many of the actions thought to be caused by testosterone in males is actually caused by estrogen signaling instead. These are some of the cool facts about estrogen signaling that were covered in the most recent Institute for Women’s Health Research hosted talk by Dr. Jeffrey Weiss, entitled, “The complexities of estrogen signaling.”

LY0Y6293

Photo: Huge Galdones

Estrogen itself can target the brain, heart, bone, breast, and the gonads in both men and women. It is lipophillic, which means it is soluble in fats rather than water. This is how estrogen can so easily pass through the fatty membranes surrounding or cells. Estrogen acts through the estrogen receptor (ER). The estrogen receptor is a protein that consists of three regions: it has a part (or domain) for binding to DNA, a domain for binding to other proteins, and a domain for binding to estrogen.

When estrogen binds to the ER, it can then work in several different ways. First, in classical signaling, the ER moves from the cell membrane to the nucleus, and binds directly to the DNA in order to cause the expression or repression of certain proteins. Second, in non-classical tethered signaling, the ER moves to the nucleus, but it binds to other proteins bound to DNA, rather than directly binding to the DNA. Lastly, in non-classical membrane signaling, the ER does not move to the nucleus, but rather binds to other proteins at the cell membrane.

It was thought that most of the actions of estrogen in the body comes from classical signaling, but recent data suggests that non-classical signaling is actually responsible for many of these effects. In fact, there are many outcomes of completely inactivating the ER in animals that are then restored by allowing only non-classical ER signaling to occur. These include the presence of large blood-filled cysts in the ovary, an underdeveloped uterus, the creation of sperm in the male, and fluid reabsorption in the testes.

This is obviously a huge field of research, but Dr. Weiss did a great job of laying the foundation for a basic understanding of the work being done. For further information, I highly recommend you check out the basic research papers that he referenced most heavily in his talk: